Spanish Fly

Spanish fly is an ancient and legendary aphrodisiac. It was made from dead, crushed insect bodies, especially the Spanish fly, which is a type of beetles from the family, Meloidae. Today, Spanish Fly is widely known as the generic world for many kinds of aphrodisiacs. These substances usually contain plants and chemical constituents, which have already been used to raise testosterone such as Maca root, Tribulus Terrestris, Crocus sativus, Turnerra difussa.[1]

For increasing libido, ambrein, a major constituent of Ambra grisea[2], is used in Arab countries. It contains tricyclic triterpene alcohol, which increases the concentration of several anterior pituitary hormones and serum testosterone.[3]

Spanish Fly is the bicyclic terpenoid

The scientist has found that the active ingredient found in Spanish Fly is the bicyclic terpenoid[4], commonly known as the cantharidin. It is usually a colorless solid when kept in room temperature, and its impacts on humans have been discovered long ago. You will notice that early physicians such as Hippocrates used round blister beetles as a prescription medicine for dropsy condition. In ancient China, round blister beetles were used for treating ulcers, piles, and rabies. This was used in ancient times, therefore, confirming whether the medicine worked is totally unclear. Something is totally clear that the Spanish Fly content of substances is a powerful substance. If a beetle blister lands on you and bites you, it instantly emits cantharidin drops that cause instant blisters, especially if it’s angry.

Cantharidin enters the skin and gets absorbed by the lipid layers. Thus, disrupting the natural formation of the transmembrane proteins that holds the cell together, causing lesions and blisters. From the 1950s, it has been used in treating molluscum contagiosum skin condition and warts also.[5] This is only prescribed under heavy restriction, and you are not supposed to go around, rubbing your skin with beetles. There are many products that tried to synthetize the effect of original Spanish fly, but many of them are considered as dangerous, e.g. Chao Jimengnan. The Food and Drug Administration is advising consumers not to purchase or use Chao Jimengnan, a product promoted for sexual enhancement on various websites.[6]

It is even more dangerous when you consume blister beetles. If this happens, cantharidin causes inflammation in the gastrointestinal tract where, if the dose is very high, it can tear the entire stomach lining. The kidneys try to remove the toxin elements from the blood, causing swelling to the urinary tract, which may appear to sexual arousal, but its something very far away and more dangerous than you may think. This means that swallowing 2 to 3 blister beetles might even kill you. You should know that Cantharidin is as toxic as strychnine and cyanide where the worst thing is that there is no antidote for it. It was used by the notorious French aristocrat, Marquis de Sade, who made prostitutes eat a box full of chocolate mixed with Spanish fly, and they luckily survived, but the notorious aristocrat was sentenced to death for attempting to murder the women.


National Center for Biotechnology Information and U.S. National Library of Medicine state that Cantharidin is natural toxin produced by the blistering beetle. It has both vesicant and keratolytic features by inducing acantholysis through targeting the desmosomal dense plaque, leading to detachment of the desmosomes from the tonofilaments. There are two available liquid preparations for dermatologic use, Canthacur (0.7% cantharidin) and Canthacur PS (1% cantharidin / 30% salicylic acid / 2% podophyllotoxin).[7]

The preparation in the past was used for the treatment of strongly expanded tubercle and molluscum contagiosum. Nowadays, it has been replaced by more sufficient cures and medicines. Even though old preparations provided painless applications with outcomes similar to modern treatments that we know today for warts and molluscum contagiosum. However, cantharidin preparation has never been approved by the Food and Drug Administration (FDA). The reason why FDA never approved cantharidin as official treatment is due to its toxic effects, which include ulceration of the gastrointestinal and genitourinary tracts, along with an electrolyte and renal function disturbance in humans and animals. The mechanism of action, dermatologic indications, application techniques, and complications of cantharidin preparations are discussed.[8]



CASRN: 56-25-7
Reviewed by SRP on 9/14/2000



Cantharidin, among the blister beetles in nature, is considered as a love potion for beetles. Before finding a mating partner, the male beetle produces cantharidin from his knees, rolls it into a sticky crystal, and places it as a crystal on his head; then it goes out to seduce the female. If the female likes the smell of the crystal, she lets the male mount on her and takes the cantharidin as an offering and uses it to smear on her unhatched eggs. The cantharidin releases a noxious substance that protects the unhatched eggs from being eaten. The males of different beetle species such as the fire-colored beetles also use cantharidin to potential mates.

The only difference is that they do not make it by themselves but has to go to the forest to look for a dying blister beetle and lick the cantharidin. Something amazing is that not only beetles and humans need/use cantharidin, but the birds such as Nuthatches also makes its nest by digging holes on trees while grabbing the blister beetles and rubbing them against the entrance of their nests, which forms a repellant, as a result of cantharidin from the blister beetles. Thus, preventing squirrels from invading their homes.

Nowadays, the use of cantharidin consumption by human beings has widely reduced, but you can still find it online. Few cases of Spanish poisoning are occasionally reported in some areas of the world.

In comparison with the toxicity of former Spanish fly, which contains Cantharidin, there are many substances that use Spanish Fly name to reflect its former libido effect. Usually, these substances are made out of different aphrodisiacs, which lead to a stronger effect. Before a person decides to buy any kind of Spanish Fly substances, he/she should be aware of these details, especially if it contains dangerous cantharidin or if it is a newer version considered as a dietary supplement. To reach the best effect within your body, many people recommend trying many aphrodisiacs one by one to see which one is most suited for you. It is sometimes difficult to find what is considered as an aphrodisiac.

In TITLE 21, chapter 1, of FOOD AND DRUGS, FDA stated that: Any product that bears labeling claims that it will arouse or increase sexual desire, or that it will improve sexual performance, is an aphrodisiac drug product.[9]

US National Library of Medicine and National Institutes of Health made an article where they described the strongest herbal aphrodisiacs known as of today, such as Mondia whitei, Chlorophytum borivilianum, Tribulus terrestris, Crocus sativus, Myristica fragrans, Phoenix dactylifera, Lepidium meyenii, Kaempferia parviflora, Eurycoma longifolia, Satureja khuzestanica, Panax ginseng, Pausinystalia yohimbe, Fadogia agrestis, Montanoa tomentosa, Terminalia catappa, Casimiroa edulis, and Turnera diffusa known as Damiana[10]. Table 1 shows all of them, including their past use. Article here.

National Institutes of Health also created a list of products that contains most used aphrodisiacs. These products are Spanish Fly Pro, Spanish Fly Love, Maxoderm, ExtenZe, VigRX Oil, Virillity Pills, ProEnhance.

In conclusion, we can say that herbal and natural dietary supplements are preferred by experts and consumers probably because of its effectiveness, few side effects, and relatively low cost.

Herbal Aphrodisiacs as spanish fly ingredient

Aphrodisiacs are used to promote a person’s sex drive, and generally boost their arousal. They can prove very useful even for patients or couples who may be struggling with their fertility. Before deciding which products to take, most people choose to visit their doctor and get a prescription for artificial drugs. These aphrodisiacs work well for many people, but some may have inhibitions about ingesting manufactured drugs.

The alternative is herbal solutions that have been proven to have an aphrodisiac effect, for both men and women. The herbs below have been used by communities all over the world for many generations, making them great natural aphrodisiacs for those looking to boost their sexual mood and performance. Many of these aphrodisiacs are used as Spanish fly ingredients, what makes Spanish fly one of the best enhancer products on the market.

Maca extract

This aphrodisiac is obtained from the root of the Maca plant, which is a perennial ground cover. The herb is gaining popularity as Spanish fly ingredient and a sexual performance-enhancing drug because of its ability to tweak one’s sexual desire. Maca extract has the advantage of being an all-natural product, and it can be used without requiring any processing or alterations. Also, it works for fertility as well, by boosting a man’s sperm count with every dosage.

Experts recommend taking 1500 mg[11] of the herb daily. Some people prefer maca extract because it works gradually, not as suddenly or immediately as other products as Spanish fly. This also means that it takes some time before beginning to wear off. That might sometimes be seen as a disadvantage for those who want a quick boost, but it also means that it has little or no side effects on the body.

L-arginine HCL

Arginine is an amino acid, one of the building blocks used to manufacture protein. It is found in foods such as meat, nuts, eggs, and even cheese. L-arginine HCL is the chemical extract of the amino acid, which is packaged as a supplement and sold in pharmacies. As an aphrodisiac, doctors recommend taking around 500 mg and 3000 mg daily, for as long as the effects are desired.[12] The amount is increased depending on how much stimulation a person’s body needs, and doctors usually advise on this. It works by increasing libido, thus making a couple desire to have sex more often.

The best thing about this root is the fact that it has a wide range of positive sexual effects, unlike most herbs which only work of one function in the body. For example, in Spanish fly it can be used to enhance arousal as well, making sex a good experience. However, L-arginine HCL can cause gastrointestinal discomfort if too much of it is used. That being said, as long as users keep their dosages within recommended limits, the aphrodisiac is very effective.


Caffeine is a stimulating compound found in food items such as coffee. Most of the population is no stranger to caffeine because multitudes of people around the world consume coffee daily as a way to boost their adrenaline and brain activity. As a herbal aphrodisiac, coffee boosts sexual activity by giving the body a lot of energy and stimulating blood flow.[13]

A cup of coffee daily should generate positive results, although coffee junkies might need to take more of it for the effects to start kicking in. The advantage is that caffeine as an aphrodisiac is readily available in almost every household, and the effects start to kick in within minutes.[14] However, taking too much of it can have the opposite effect, decreasing sexual drive. Here, moderation is key. As long as a person can stay within the limits, coffee is the perfect natural aphrodisiac and that is the reason why is it used widely in Spanish fly.

Panax ginseng

This herb is more popularly known as red ginseng. It is widely grown in Korea, where it has been used for centuries as a herbal medicine for the skin, the digestive system, as well as an aphrodisiac. One can buy the red ginseng root and cook it for eating. Unlike other supplements or stimulants, it does not need to be taken daily. It should be consumed when needed. Panax ginseng works by relaxing the muscles and improving blood flow during sex. The herb may have negative side effects if too much of it is used. For example, it can cause insomnia due to its stimulant properties. That being said, as Spanish fly ingredient it is great for enhancing sexual activity in an all-natural way.


Guarana is a climbing shrub with origins in South America. The extract is added to soft drinks and alcoholic drinks to act as a stimulant. It works by exciting the nerves, heightening the sexual experience. It can be taken while in a soft drink, making it enjoyable to consume. The guarana begins to take effect almost immediately, except if a person has cultivated a high tolerance for it. The con is that guarana does not have any effect on a person’s hormones, so it cannot be used effectively as a long-term stimulant. Even so, it is extremely easy to consume.

Tribulus Terrestris

This herb is also a herb that grows as a ground cover. Tribulus terrestris (TT) is a traditional herbal medicine used to enhance sexual activities.[15] It is best used as an aphrodisiac by women because it promotes sexual arousal. One should take around 750 mg daily, for about four months to improve overall sex drive. The herb is great because it affects many sexual functions, including desire, arousal, and performance. The drawback is that it can cause discomfort in the digestive tract if too much is taken. The herb works really well and with a wide scope.

Zinc gluconate

Zinc gluconate is a supplement containing zinc, a very important mineral for great sexual health. It should only be taken if the body has a zinc deficiency, otherwise, it will not have the desired effects. Zinc gluconate is taken daily as a tablet until zinc levels in the body are restored.

Spanish Fly in the Past


The male Spanish Fly, also known as the Blister Beetle, excretes a liquid called Cantharidin to seduce his female counterpart. The female then uses the same secretions to coat and protect her eggs. However, these green beetles are not the only ones using Cantharidin[16] to kick the romance into gear. People have been using this aphrodisiac for thousands of years, but they haven’t all used it in the same way.

The History of Medicinal Use

Centuries ago, people began using crushed Blister Beetle for healing injuries. In China, it was originally used as the foundation for stink bombs, before they moved on to aphrodisiacs. If that doesn’t get you wound up, I’m not sure what will! The Chinese also used it to treat piles, ulcers and even rabies. And, you guessed it, this versatile little insect has a long history of being involved in sexual conquests among the wealthy and royal.

The Romans would probably prefer their historical misuse of Spanish Fly go unnoted. However, Augustus Caesar’s wife ensured a place in history when she used it to entice romantic interludes among guests whom she later blackmailed. King Henry IV used Cantharidin to seduce women and persuade them to participate in orgies. He is not alone, as there are long lists of people who have used it for similar purposes, and even wives putting it in recipes to encourage amorous behavior from their husbands.

In the 1600’s, Cantharidin was a banned substance in France, but that didn’t stop wealthy French residents from using extensive amounts. A French sorceress was known for making love potions with Spanish Fly. The wealthy didn’t just use Spanish Fly to encourage romance, they also used it (in large doses) as a poison to murder. Eventually, people realized that the Cantharidin induced erections in men and could be used on animals, making it a useful tool for mating animals. In some areas of the world, it is still used in this form today. However, there have been cases of animals as large as horses dying from ingesting Spanish Fly, so it is not recommended for animal husbandry (or animal ingestion at all).

Libido aside, Spanish Fly was used throughout time to treat many other ailments, including water retention from heart disease, ear aches, a wart remover, kidney problems, internal inflammation and even to treat burns. The Chinese used Spanish Fly to treat Molluscum Contagiosum, a form of pox disease. In the late 1800s, Spanish Fly was used as a possible treatment and prevention for smallpox. Eventually, the aphrodisiac benefits of Spanish Fly were touted as a treatment for any sexual ailment, including impotence or lack of sexual desire. However, the toxins found in Spanish Fly were not creating an erotic response but instead triggering inflammation that presented in the form of an erection or swollen labia. The tingling from the substance was often mistaken for sexual pleasure. In reality, it could be very uncomfortable and even poisonous, with some people dying after using Spanish Fly.

Spanish Fly Use Today


There are still incidents where Spanish Fly is used to remove warts and tattoos, although the safety of this method is not confirmed. Spanish Fly drops are readily available on the market today, as an aphrodisiac or libido enhancer, but without the crushed beetles. Presumably, these modern drops have tested toxicity levels and create a much safer product for people looking to spice up their love lives. They are not considered drugs but a natural supplement made from natural ingredients.

So, it seems that the new Spanish Fly[17] has the benefits of increased sexual desire and acts as an aphrodisiac, but doesn’t have the same side effects or dangerous toxicity because there is little to no actual Spanish Fly in the recipe. All of the ingredients are FDA approved and entirely safe for use.

If you could use some help in the bedroom, don’t shy away from Spanish Fly because it carries the name of a historically poisonous method of increasing sexual desire.[18] Today, it is just a fun name that reminds us that the problems of today are not that different from those in the past. Thousands of years later, we are still looking for ways to increase our pleasure and enjoyment in life. Thankfully, now we can ensure we don’t accidentally harm ourselves in the process!

Recent Studies of Spanish Fly


Today, the Chinese and Vietnamese use Spanish Fly as a natural treatment for cancer, but there is no medical backing for the validity of it as a cancer treatment. However, there are studies underway to test the benefits of Spanish Fly for treating cancer, as there is evidence that it would be beneficial for refractory tumors.

However Spanish Fly is used today, no one could ever say that it didn’t have an interesting and sordid history.

To make sure you don’t end up part of that history, read reviews and do research on all Spanish Fly drops or supplements before using them, because you don’t want to be the unlucky one who orders Spanish Fly that actually has some blister beetles in it (don’t worry, you won’t – it’s not legal). Whether or not Spanish Fly actually works as an aphrodisiac will depend on each individual. The herbs may have libido enhancing effects for one person and not for another, but one thing that is consistent with most people is that the suggestion of romance and sexual pleasure can conjure up exactly what you desire.

What taste does Spanish Fly have?

There are multiple types of Spanish Fly products, which means that they all have different tastes. Some of the products have a fresh taste, while others don’t have any type of taste at all. Once you know the number of drops to consume, you can mix it with any type of preferred drink, which includes alcoholic beverages, soda, juice and water.

Note: Spanish Fly won’t change the taste of any beverage with which you choose to mix it. Using it with your favorite drink will simply taste like you are adding drops of water.

Is Spanish Fly safe to use?

Spanish Fly aphrodisiac is 100 percent safe. It’s a libido booster that has been used for centuries as a natural aphrodisiac. The only side effects some users have experienced are a result of misuse or an overdose. If you are going to use Spanish Fly, ensure that you only use it as per the recommended dosage. It’s an effective aphrodisiac that creates a lot of thrills and takes you to the next level of sexual dimension. However, don’t be tempted to increase the number of drops per intake, as this is harmful.

The FDA compliant product is usually infused with herbal ingredients and is well tolerated by a lot of users. If you are ready for some great intimate time with your partner, then Spanish Fly is for you. Rest assured that you will be delighted and even want more. In correct doses, there are no negative side effects associated with the use of Spanish Fly – just be sure to buy a quality product that is well-labeled and from a reputable seller.

What is the Active Ingredient in Spanish Fly?

Previously, the main active ingredient that was used to formulate Spanish Fly was Cantharidin, a chemical found in blister beetles and had significant vesicant effects that were harmful. The use of Cantharidin by human beings is not approved by the FDA, which means that the old version of Spanish Fly that was formulated with Cantharidin is illegal for use.

Cantharidin has been used for ages as a powerful sexual stimulant, and it was used with Spanish Fly in small amounts since ingesting it in high amounts can be toxic. It’s associated with side effects such as nausea, burning of the mouth, dysuria and hematemesis. Additionally, this compound can damage the stomach, genitals and be potentially fatal. For this reason, Spanish Fly products no longer contain Cantharidin. Instead, they are now being formulated with a wide range of high-quality plant-based extracts that include Maca, Guarana, Tribulus Terrestris and coffee, among others.

Spanish Fly is sometimes considered as Drug

Spanish Fly is not a drug. It is an aphrodisiac that contains multiple plant-based extracts. It is specifically formulated to increase sexual arousal. There are numerous versions of Spanish Fly that are found on the market and most of them are compliant with FDA regulations. Additionally, they are highly effective. At the moment, there are more than seven brands of Spanish Fly.

These product versions have been designed to increase sexual libido or reignite sexual urges in older couples who have lost their sexual desire, young couples who are stressed about having sex for the first time, women who have lost sexual urges after childbirth and men and women who are actively dating and engaging in sex but want to spice up their bedroom activities.

Note: there is no such thing as a Spanish Fly drug. This aphrodisiac is a non-prescription organic supplement that enhances libido. There are numerous products that are normally marketed as Spanish Fly. The truth is that none of them are formulated with the original ingredients, which are found in this aphrodisiac. At the moment, Spanish Fly as a brand name has quickly evolved from a product that’s associated with libido enhancement. There are wide ranges of wellness products, including supplements from companies that sell products with the Spanish Fly label. Don’t rush to purchase them thinking that they’ll boost your libido. Purchase items from a reputable seller and ensure that you check the label, as well as customer reviews, to ascertain their effectiveness.


Is Spanish Fly actually effective?

Yes, it does. This aphrodisiac is 100 percent effective. You don’t have to wait for long, since its effects can be experienced in less than 10 minutes. Mix a few drops with your favorite drink and sit back as you wait for your partner to prepare. As soon as you ingest Spanish Fly, you will experience an intense sexual urge that may even overpower you. It works for both men and women and produces great effects by increasing libido and enhancing strong orgasms. It basically takes your normal sex life to a whole new level.

The correct dosage depends on your sexual preferences. But generally, a few drops of Spanish Fly can result in a huge difference when it comes to your sexual performance. Always make sure that you use the recommended number of the drops to avoid unnecessary side effects. If you have been having trouble attaining orgasm, be prepared to get the best and most pleasurable orgasms you’ve ever experienced.

Spanish Fly and legal aspects

Spanish Fly products are made with herbal or plant-based ingredients. The FDA does not restrict the use of herbal extracts for use in supplements. All the ingredients that are used to make Spanish Fly are compliant with FDA requirements; hence, it is not illegal for use in the US. All the ingredients are 100 percent natural and safe and effective for human consumption. Spanish Fly is prepared naturally and is free of artificial ingredients including preservatives and sweeteners. You can take it every day without having to worry about any kind of adverse side effects. It’s great for women and men of all legal ages.


These herbal aphrodisiacs have been tried and tested for decades and even centuries, making them a safe and healthy option for those in need of better sex lives. The most important thing is always to take them in the recommended amounts and for the stated number of days to avoid any undesired side effects. The best herb for a person depends on their specific needs because all of them have different effects. Also, it is wisest to purchase them from reliable sources like well-known pharmacies, organic food markets, or from established company brands. This way, a customer can be sure that they are getting exactly what they want.


[1] G.F. KingVenoms as a platform for human drugs: translating toxins into therapeutics

Expert Opin Biol Ther, 11 (2011), pp. 1469-1484


[3] Sandroni P. Aphrodisiacs past and present: A historical review. Clin Auton Res. 2001;11:303–7.

[4] Article in Organic Geochemistry 7(3-4):231-238 · December 1984

[5] Wang HZ, Lee SW, Christ GJ. Comparative studies of the maxi-K (K (Ca)) channel in freshly isolated myocytes of human and rat corpora. Int J Impot Res. 2000;12:9–18.



[8] Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 174





[13] aphrodisiac-men

[14] El-Shimi MS, Awad HA, Abdelwahed MA, Mohamed MH, Khafagy SM, Saleh G. Enteral L-Arginine and Glutamine Supplementation for Prevention of NEC in Preterm Neonates. Int J Pediatr. 2015;2015:856091. doi: 10.1155/2015/856091. Epub 2015 Mar 12.

[15] Paice JA, Penn RD, Ryan WG. Altered sexual function and decreased testosterone in patients receiving intraspinal opioids. J Pain Symptom Manage. 1994;9(2):126–131. [PubMed]





About Author

TJ Gusman has all formal qualifications include a PhD from The University of Texas, USA. The PhD, entitled to structural changes of Aphrodisiacs compounds: A Case Study of aplicable aphrodisiacs and their influence on human body. These influences are not always deterministic. The study also showed use of aphrodisiacs in mixtures such as spanish fly drops.

About Us

“We are a large pharmaceutic organization of US which contains specialized doctors, experts, and researchers in the field of sexual enhancers (spanish fly) and sexual problems. As we specialize in sex-related problems and enhancer products then we can have a number of experiences in this regard as experts.” – Paul Starker, M. D. & CEO